January 21-22, 2023, Virtual Conference
ChristianahAdebimpe Dare1 and OluokunOluboade Oyedapo2, 1Department of Biochemistry, Osun State University, Osogbo, Nigeria, 2Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Nigeria
This study extracted and optimised polysaccharides from cotyledon of fermented and unfermented A. squamosa. It also fractionated, analysed the structures and evaluated the antioxidant and anti-inflammatory potentials of the purified polysaccharides. Fresh and ripe sugar apple fruits were collected from an orchard at Ota-Efun, Olorunda Local Government, Osogbo, Nigeria (07o32 30.2496 N, 04o 31 41.7036 E) and their identity authenticated. A portion of the seeds was fermented and the rest unfermented, and the cotyledon was separated from the seed coat. Water-soluble polysaccharides extraction was carried out according to standard methods. The antioxidant and anti-inflammatory potentials of the polysaccharides were assessed using standard methods. The results of these analyses showed that the polysaccharides from fermented and unfermented cotyledon of A. squamosa are great candidates as antioxidant agents to take care of oxidative stress and its accompanying metabolic diseases. Howevr, fermentation enhanced the activities of the polysaccharides in the cotyledon.
Fermentation, Reactive Species, Free Radicals, Phytochemicals, Medicinal Plants.
Thanh Tu Nguyen1, Trinh Le Thi Nguyen2 and Minh Thai Nguyen1, 1Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh city, Vietnam, 2Faculty of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh city, Vietnam
In this research, R. toruloides fermentation medium has been successfully investigated included: glucose 5 g/L, NaCl 8 g/L, H2O2 5.2 mL/L, KH2PO4 2.5 g/L, MgSO4.7H 2 O 2 g/L, NH4Cl 2 g/L, Na2HPO4 6 g/L, yeast extract 5 g/L, pH 5,6 ± 0.2. R. toruloides achieved 4.57 g/L (average result) dry biomass rich in carotenoids from the aforesaid optimum formula after 120 h of culture, with an average carotenoid concentration of 31.44 g/g. After re-evaluating the ideal model experimentally, the dry biomass according to the predicted model and the experimental model had a high compatibility of 99.3%. Furthermore, the predicted carotenoid concentration was 95.2% higher than the experimental one. Furthermore, the residual glucose content after culture is quite low (24.7 - 48.). R. toruloides efficiently utilised the glucose supply for carotenoids development (g/mL or 0.0247 - 0480 g/L).
R. toruloides, biomass, carotenoids, optimization, fermentation, surface response.
Abdul Kader Mohiuddin, Alumni, Faculty of Pharmacy, Dhaka University, Bangladesh
Proper use of medicine or taking medicine in correct order is essential to cure any disease. Even patients from developed nations have trouble staying on top of their drug compliance. When it comes to improper medicine use, there is an odd parallel between underdeveloped, emerging nations and the so-called developed world in the West. The key factor influencing whether patients stick to their treatment plan is their understanding and perception of the disease.
Patient compliance, Healthcare denials, Medication adherence, Elderly patient care, Treatment failure.
Aysenaz Ezgi Ergin and Deniz Turgay Altılar, Department of Computer Engineering, Istanbul Technical University, Istanbul, Turkey
The major histocompatibility complex (MHC) molecules, which bind peptides for presentation on the cell surface, play an important role in cell-mediated immunity. In the light of developing database and technologies over the years, significant progress has been made in studies on peptide binding af inity calculation. Several in techniques have been developed to predict peptide binding to MHC class I.Most of the studies on MHC Class I due to its nature bring better performance and are more, this study has been examined on both MHC Class I and MHC Class II. Considering the use of diferent methods and dif erent technologies, and the approach of similar methods on dif erent proteins, a classification was created according to the binding af inity of protein peptides. For this classification, MHC Class I was studied using the MHCflurry,NetMHCPan,NetMHC , IEDBNetMHCCons , IEDBNetMHCPan, and random generator.For this classification, MHC Class I was studied using the MHCflurry,NetMHCPanII,NetMHC , IEDBNetMHCCons , IEDBNetMHCPan, and random generator.In addition, in this study, a general simple explanation is aimed for the novice and non-expert researchers to calculate the protein binding af inity. There is no general superior model in the models used. It has been determined that they are superior to each other in various points. In this study, it is aimed to label many models as strong, weak, moderate or incalculable by giving weight to the suitability of the protein to the model.
MHC I, HLA I, binding af inity, mhcflurry, netmhcpan, netomhc, netmhccons, ssmpmbec.
Marina Nagervadze1,3, Jilda Gobadze1, Sophiko Tskvitinidze2,3, Rusudan Khukhunaishvili1, Ketevan Dolidze1, Leila Akhvlediani1,3, Tea Koiava2, Marina Koridze1 ,1Department of Biology, Batumi Shota Rustaveli State University, Batumi, Georgia, 2Department of clinical medicine, Batumi Shota Rustaveli State University, Batumi, Georgia, 3BAU International University of Batumi, Batumi, Georgia
Individualism of the human being is related to its own biological characteristics. In our modern time, there are a lot of methods for the identification of the personality. The fingerprint method is the ancient and the most common method among the other biometric identification methods, which uses the physiological and morphological characteristics of the organisms. The fingerprint method is frequently used for the identification of criminals. Each fingerprint is composed of specific papillae and rete ridges. Each person has his/her unique papillary fingerprint pattern that makes characteristic individualism. The finger’s ridges on the right and left hand are unique, developed prenatally, and don’t alter with growth or age. Dermatoglyphics, the science about skin epidermal ridge patterns of the fingers and toes have been widely linked with anthropology and population genetics. It is very useful for the assessment of population structure. Human being fingerprint is classified into three categories: “Loop”, “Whorl”, and “Arche”. The distribution of these fingerprint categories is slightly different in different geographic areas. Our study interest was to analyze the quantitative specific characteristic of primary fingerprints in the secondary and high school students in the population of Adjara (Georgia republic).
Fingerprint, papillae and rete ridges, Adjara population.
Nazrin Talibova, Huseyin Alparslan Shahin and Aydin Deveci, Department of Psychology, Ondokuz Mayis University, Samsun, Turkey
In this research, it is aimed to evaluate the frontal area in HIV patients in detail through neuropsychological tests. Neuropsychological test battery to assess cognitive changes caused by HIV infection in HIV-infected patients; WCST, Stroop Test, Trail Making Test, Digit Span Test, Clock Drawing Test, Boston Naming Test, Cube Design Test, California Test and Hamilton Depression Rating Scale were applied. 43 volunteer patients diagnosed with HIV, aged between 18 and over, were included in the study. EEG and MRI results of the patients taken in the last 6 months were examined, and patients with lesions and patients with severe depression were excluded from the study. The study included criteria such as educational status, initial CD4 + T lymphocyte cell count, and duration of illness. When the relationship between the CD4 + groups on neuropsychological test scores, education levels and depression scores was examined, the analysis results of the CD4 + groups according to Hamilton test scores and California subtest scores were found to be statistically significant. There was no significant relationship between the duration of illness and test scores. Correlation analysis was not found significant according to the neuropsychological test scores of the Hamilton test. At the same time, no statistically significant difference was found between CD4 + groups according to education levels.
HIV, neuropsychological tests, frontal functions.